BAIT
NDN
HsT16328, PWCR
necdin, melanoma antigen (MAGE) family member
GO Process (2)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
PREY
CORO1B
CORONIN-2
coronin, actin binding protein, 1B
GO Process (10)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- actin cytoskeleton organization [IBA]
- actin filament branching [IDA]
- actin filament bundle assembly [IDA]
- cell migration [IDA]
- endothelial cell chemotaxis [IDA]
- negative regulation of Arp2/3 complex-mediated actin nucleation [IDA]
- positive regulation of lamellipodium morphogenesis [IDA]
- protein localization to cell leading edge [IDA]
- ruffle organization [IDA]
- wound healing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the loss of function of a set of imprinted genes on chromosome 15q11-15q13. One of these genes, NDN, encodes necdin, a protein that is important for neuronal differentiation and survival. Loss of Ndn in mice causes defects in the formation and function of the nervous system. Necdin is a member of ... [more]
Hum Genet Dec. 01, 2020; 139(12);1513-1529 [Pubmed: 32529326]
Throughput
- High Throughput
Curated By
- BioGRID