BAIT
MAPK14
CSBP2, Crk1, Csbp1, Mxi2, PRKM14, PRKM15, p38, p38-alpha, p38MAPK, p38a, p38alpha, RP24-137E7.1
mitogen-activated protein kinase 14
GO Process (43)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- angiogenesis [IMP]
- cartilage condensation [IMP]
- cell morphogenesis [IGI]
- cellular response to DNA damage stimulus [IDA]
- cellular response to ionizing radiation [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- chondrocyte differentiation [IDA, IMP]
- fatty acid oxidation [IMP]
- glucose metabolic process [IMP]
- intracellular signal transduction [IDA, ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- myoblast differentiation involved in skeletal muscle regeneration [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- osteoclast differentiation [IMP]
- p38MAPK cascade [IDA]
- peptidyl-serine phosphorylation [IDA]
- placenta development [IMP]
- positive regulation of brown fat cell differentiation [IMP]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of myoblast fusion [IMP]
- positive regulation of myotube differentiation [IMP]
- positive regulation of protein import into nucleus [IMP]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- response to lipopolysaccharide [IDA]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IMP]
- signal transduction in response to DNA damage [ISO]
- skeletal muscle tissue development [IMP]
- stress-activated MAPK cascade [ISO]
- stress-induced premature senescence [ISO]
- striated muscle cell differentiation [IGI]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IGI]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NUDT21
Cpsf5
nudix (nucleoside diphosphate linked moiety X)-type motif 21
GO Process (3)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID