BAIT
MAPK11
P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2
mitogen-activated protein kinase 11
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RYR2
RYR-2, RyR
ryanodine receptor 2, cardiac
GO Process (42)
GO Function (16)
GO Component (20)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- Purkinje myocyte to ventricular cardiac muscle cell signaling [ISO]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [ISO, ISS]
- calcium ion transport into cytosol [ISO]
- calcium-mediated signaling [ISO, ISS]
- calcium-mediated signaling using intracellular calcium source [ISO]
- canonical Wnt signaling pathway [ISO]
- cardiac muscle contraction [ISO]
- cardiac muscle hypertrophy [ISO]
- cellular calcium ion homeostasis [ISO, ISS]
- cellular response to caffeine [ISO, ISS]
- cytosolic calcium ion homeostasis [IMP]
- cytosolic calcium ion transport [ISO]
- detection of calcium ion [ISO]
- embryonic heart tube morphogenesis [ISO, ISS]
- establishment of protein localization to endoplasmic reticulum [ISO]
- ion transmembrane transport [IMP]
- left ventricular cardiac muscle tissue morphogenesis [ISO]
- manganese ion transmembrane transport [IMP]
- negative regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of calcium-transporting ATPase activity [ISO]
- positive regulation of heart rate [ISO]
- positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [ISO]
- positive regulation of sequestering of calcium ion [ISO]
- positive regulation of the force of heart contraction [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISO]
- regulation of heart rate [ISO]
- release of sequestered calcium ion into cytosol [ISO]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISO]
- response to caffeine [ISO]
- response to calcium ion [IDA]
- response to drug [IEP]
- response to hypoxia [ISO]
- response to magnesium ion [IDA]
- response to muscle stretch [ISO]
- response to nutrient [IEP]
- response to redox state [ISO]
- sarcoplasmic reticulum calcium ion transport [IMP]
- type B pancreatic cell apoptotic process [ISO]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- calcium channel activity [ISO, ISS]
- calcium-induced calcium release activity [IDA, ISO]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- intracellular ligand-gated calcium channel activity [ISO, ISS]
- organic cyclic compound binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [ISO]
- protein self-association [ISO]
- ryanodine-sensitive calcium-release channel activity [IDA, IMP, ISO]
- scaffold protein binding [IPI]
- suramin binding [ISO]
- calcium channel activity [ISO, ISS]
- calcium-induced calcium release activity [IDA, ISO]
- calcium-release channel activity [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- intracellular ligand-gated calcium channel activity [ISO, ISS]
- organic cyclic compound binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [ISO]
- protein self-association [ISO]
- ryanodine-sensitive calcium-release channel activity [IDA, IMP, ISO]
- scaffold protein binding [IPI]
- suramin binding [ISO]
Gene Ontology Cellular Component
- A band [IDA]
- Z disc [IDA, ISO]
- calcium channel complex [ISO]
- cell [ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- endoplasmic reticulum [IDA]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IDA]
- intracellular [ISO]
- membrane [ISO]
- neuron projection [IDA]
- nuclear envelope [IDA]
- plasma membrane [IDA]
- protein complex [IDA, ISO]
- sarcolemma [IDA]
- sarcomere [ISO]
- sarcoplasmic reticulum [IDA, ISO]
- sarcoplasmic reticulum membrane [IDA, ISO]
- smooth endoplasmic reticulum [ISO]
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID