BAIT
MAPK11
P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2
mitogen-activated protein kinase 11
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NRP1
Nrp
neuropilin 1
GO Process (55)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISO]
- VEGF-activated neuropilin signaling pathway involved in axon guidance [ISO]
- angiogenesis [ISO]
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- artery morphogenesis [ISO]
- axon extension involved in axon guidance [ISO]
- axon guidance [IMP, ISO]
- axonal fasciculation [ISO]
- axonogenesis involved in innervation [ISO]
- cell migration [ISO]
- cell migration involved in sprouting angiogenesis [ISO]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- commissural neuron axon guidance [ISO]
- coronary artery morphogenesis [ISO]
- dendrite development [ISO]
- dichotomous subdivision of terminal units involved in salivary gland branching [ISO]
- endothelial cell chemotaxis [ISO]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [ISO]
- heart development [ISO]
- hepatocyte growth factor receptor signaling pathway [ISO]
- negative regulation of axon extension [ISO]
- negative regulation of axon extension involved in axon guidance [IMP, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [ISO]
- nerve development [ISO]
- nervous system development [NAS]
- neural crest cell migration involved in autonomic nervous system development [ISO]
- neuron development [ISO]
- neuron migration [ISO]
- patterning of blood vessels [ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive chemotaxis [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of axon extension involved in axon guidance [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of retinal ganglion cell axon guidance [ISO]
- protein localization to early endosome [ISO]
- regulation of axon extension involved in axon guidance [ISO]
- regulation of retinal ganglion cell axon guidance [ISO]
- renal artery morphogenesis [ISO]
- response to wounding [IEP]
- retina vasculature morphogenesis in camera-type eye [ISO]
- retinal ganglion cell axon guidance [ISO]
- semaphorin-plexin signaling pathway [ISO]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISO]
- sprouting angiogenesis [ISO]
- sympathetic ganglion development [ISO]
- sympathetic nervous system development [ISO]
- sympathetic neuron projection extension [ISO]
- sympathetic neuron projection guidance [ISO]
- toxin transport [ISO]
- trigeminal nerve morphogenesis [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID