BAIT
MAPK11
P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2
mitogen-activated protein kinase 11
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CALR
calreticulin
GO Process (31)
GO Function (13)
GO Component (21)
Gene Ontology Biological Process
- cardiac muscle cell differentiation [IEP]
- cell cycle arrest [ISO]
- cellular response to lithium ion [IEP]
- cellular response to organic substance [IEP]
- cellular senescence [ISO]
- chaperone-mediated protein folding [IMP]
- cortical actin cytoskeleton organization [ISO]
- negative regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of retinoic acid receptor signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of translation [IDA]
- peptide antigen assembly with MHC class I protein complex [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of dendritic cell chemotaxis [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of phagocytosis [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein export from nucleus [ISO]
- protein folding [TAS]
- protein localization to nucleus [ISO]
- protein stabilization [ISO, ISS]
- regulation of meiosis [ISO]
- response to drug [IEP]
- response to estradiol [IEP]
- response to organic substance [IEP]
- response to testosterone [IEP]
- spermatogenesis [IEP]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [ISO]
- glycoprotein binding [IPI, ISO]
- hormone binding [IPI]
- integrin binding [ISO]
- iron ion binding [IDA]
- mRNA binding [IDA, ISO]
- peptide binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IMP]
- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [ISO]
- glycoprotein binding [IPI, ISO]
- hormone binding [IPI]
- integrin binding [ISO]
- iron ion binding [IDA]
- mRNA binding [IDA, ISO]
- peptide binding [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [IMP]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- MHC class I peptide loading complex [ISO]
- acrosomal vesicle [IDA]
- cell surface [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- endoplasmic reticulum [IDA, ISO, TAS]
- endoplasmic reticulum lumen [ISO]
- external side of plasma membrane [ISO]
- extracellular matrix [IDA]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- polysome [ISO]
- protein complex [IDA]
- sarcoplasmic reticulum [IDA]
- smooth endoplasmic reticulum [IDA]
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID