BAIT
MAPK11
P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2
mitogen-activated protein kinase 11
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MAP2K1
Mek1
mitogen activated protein kinase kinase 1
GO Process (35)
GO Function (9)
GO Component (18)
Gene Ontology Biological Process
- Golgi inheritance [IMP]
- MAPK cascade [IMP, ISO]
- activation of MAPK activity [IDA, ISO, TAS]
- cell cycle arrest [ISO]
- cell motility [ISO]
- cell proliferation [IDA]
- cellular senescence [ISO]
- intracellular signal transduction [TAS]
- keratinocyte differentiation [ISO]
- labyrinthine layer development [ISO]
- melanosome transport [IDA]
- mitotic nuclear division [IDA]
- negative regulation of cell proliferation [ISO]
- negative regulation of homotypic cell-cell adhesion [IMP]
- neuron differentiation [IMP, ISO]
- neuron projection morphogenesis [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- placenta blood vessel development [ISO]
- positive regulation of Ras GTPase activity [IMP]
- positive regulation of Ras protein signal transduction [IMP]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [IMP]
- protein heterooligomerization [IPI]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of stress-activated MAPK cascade [TAS]
- regulation of vascular smooth muscle contraction [IMP]
- response to axon injury [IMP]
- response to glucocorticoid [IDA]
- response to oxidative stress [IDA]
- vesicle transport along microtubule [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase kinase activity [IDA, IMP, ISO, TAS]
- Ras GTPase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IDA, IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [ISO]
- ATP binding [IDA]
- MAP kinase kinase activity [IDA, IMP, ISO, TAS]
- Ras GTPase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IDA, IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activator activity [ISO]
- protein serine/threonine/tyrosine kinase activity [TAS]
- receptor signaling protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, TAS]
- axon [IDA]
- cell cortex [IDA]
- cytoplasm [ISO]
- cytosol [IDA, TAS]
- dendrite [IDA]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule [IDA]
- mitochondrion [TAS]
- nucleus [TAS]
- perikaryon [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID