BAIT
MAPK11
P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2
mitogen-activated protein kinase 11
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAB1A
Ac2-048, Rab1, Rab1r
RAB1A, member RAS oncogene family
GO Process (15)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IDA, ISO]
- GTP catabolic process [IBA, ISS]
- Rab protein signal transduction [IBA, IC]
- autophagic vacuole assembly [IBA, ISS]
- autophagy [ISS]
- cell migration [ISS]
- defense response to bacterium [ISS]
- endocytosis [IMP]
- growth hormone secretion [ISS]
- interleukin-8 secretion [ISS]
- intracellular protein transport [IBA]
- positive regulation of glycoprotein metabolic process [ISO]
- regulation of autophagic vacuole assembly [ISO]
- vesicle transport along microtubule [IMP]
- virion assembly [ISO]
Gene Ontology Molecular Function- GDP binding [IBA]
- GTP binding [IDA, ISO]
- GTPase activity [IBA, ISS]
- GDP binding [IBA]
- GTP binding [IDA, ISO]
- GTPase activity [IBA, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID