BAIT
MAPK11
P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2
mitogen-activated protein kinase 11
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PAFAH1B1
LIS1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
GO Process (36)
GO Function (8)
GO Component (22)
Gene Ontology Biological Process
- acrosome assembly [ISO]
- actin cytoskeleton organization [ISO]
- adult locomotory behavior [ISO]
- ameboidal-type cell migration [ISO]
- brain development [IEP]
- brain morphogenesis [ISO]
- cell migration [ISO]
- cerebral cortex development [ISO]
- cerebral cortex neuron differentiation [IMP]
- corpus callosum morphogenesis [ISO]
- establishment of centrosome localization [IMP]
- establishment of mitotic spindle orientation [ISO]
- hippocampus development [ISO]
- layer formation in cerebral cortex [ISO]
- learning or memory [ISO]
- microtubule cytoskeleton organization [ISO]
- microtubule organizing center organization [ISO]
- microtubule-based process [ISO]
- negative regulation of JNK cascade [ISO]
- negative regulation of neuron projection development [IMP]
- neuroblast proliferation [ISO]
- neuromuscular process controlling balance [ISO]
- neuron migration [IMP, ISO]
- nuclear envelope disassembly [ISO]
- nuclear migration [IMP]
- osteoclast development [ISO]
- positive regulation of axon extension [IMP]
- positive regulation of cytokine-mediated signaling pathway [ISO]
- positive regulation of mitotic cell cycle [IMP]
- protein secretion [ISO]
- regulation of Rho GTPase activity [ISO]
- retrograde axon cargo transport [ISO]
- stem cell division [IMP]
- synaptic transmission [ISO]
- transmission of nerve impulse [ISO]
- vesicle transport along microtubule [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- astral microtubule [ISO]
- axon [IDA]
- cell [ISO]
- cell cortex [ISO]
- cell leading edge [ISO]
- centrosome [ISO]
- cytoplasm [ISO]
- cytosol [IDA]
- extracellular vesicular exosome [ISO]
- growth cone [IDA]
- intracellular [ISO]
- kinesin complex [IDA]
- kinetochore [ISO]
- microtubule associated complex [ISO]
- microtubule cytoskeleton [ISO]
- motile primary cilium [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nonmotile primary cilium [ISO]
- nuclear envelope [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- vesicle [IDA]
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID