BAIT
MAPK11
P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2
mitogen-activated protein kinase 11
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PDE2A
Pde2, Pde2a2
phosphodiesterase 2A, cGMP-stimulated
GO Process (22)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- cAMP catabolic process [IDA, ISO]
- cAMP-mediated signaling [IMP, ISO]
- cGMP catabolic process [IDA, ISO]
- cGMP-mediated signaling [ISO, ISS]
- cellular response to cGMP [ISO, ISS]
- cellular response to drug [ISO, ISS]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO, ISS]
- cellular response to macrophage colony-stimulating factor stimulus [ISO, ISS]
- cellular response to mechanical stimulus [ISO, ISS]
- cellular response to transforming growth factor beta stimulus [ISO]
- establishment of endothelial barrier [IDA]
- metabolic process [ISO]
- monocyte differentiation [ISO]
- negative regulation of cAMP biosynthetic process [IMP, ISO]
- negative regulation of protein import into nucleus, translocation [ISO, ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- negative regulation of vascular permeability [ISO, ISS]
- positive regulation of gene expression [ISO]
- positive regulation of inflammatory response [ISO, ISS]
- positive regulation of vascular permeability [ISO, ISS]
- protein targeting to mitochondrion [IMP]
- regulation of cGMP metabolic process [ISO]
Gene Ontology Molecular Function- GAF domain binding [ISO]
- TPR domain binding [ISO]
- cAMP binding [IDA, ISO]
- cGMP binding [IDA, ISO]
- cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [IDA, ISO]
- cyclic-nucleotide phosphodiesterase activity [ISO, ISS]
- drug binding [ISO, ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA, ISO]
- GAF domain binding [ISO]
- TPR domain binding [ISO]
- cAMP binding [IDA, ISO]
- cGMP binding [IDA, ISO]
- cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [IDA, ISO]
- cyclic-nucleotide phosphodiesterase activity [ISO, ISS]
- drug binding [ISO, ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA, ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO, ISS]
- axon [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO, ISS]
- dendrite [ISO]
- endoplasmic reticulum [ISO, ISS]
- intracellular [ISO]
- membrane raft [IDA]
- mitochondrial matrix [IDA]
- nucleus [ISO, ISS]
- perinuclear region of cytoplasm [ISO, ISS]
- plasma membrane [ISO, ISS]
- presynaptic membrane [ISO, ISS]
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID