BAIT
MAPK11
P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2
mitogen-activated protein kinase 11
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NME1
NME/NM23 nucleoside diphosphate kinase 1
GO Process (17)
GO Function (15)
GO Component (10)
Gene Ontology Biological Process
- DNA catabolic process [ISO]
- cellular response to drug [IEP]
- cellular response to fatty acid [IEP]
- cellular response to glucose stimulus [IEP]
- hippocampus development [IEP]
- lactation [ISO]
- mammary gland development [ISO]
- negative regulation of gene expression [IDA]
- negative regulation of myeloid leukocyte differentiation [IDA]
- nucleoside diphosphate phosphorylation [IDA]
- positive regulation of DNA binding [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of neuron projection development [IMP]
- response to amine [IEP]
- response to cAMP [IEP]
- response to drug [IEP]
- response to testosterone [IEP]
Gene Ontology Molecular Function- ATP binding [ISO]
- GTP binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- deoxyribonuclease activity [ISO]
- enzyme binding [IPI]
- gamma-tubulin binding [IDA]
- identical protein binding [ISO]
- intermediate filament binding [IPI]
- magnesium ion binding [ISO]
- nucleoside diphosphate kinase activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- ribosomal small subunit binding [ISO]
- single-stranded DNA binding [IDA]
- ATP binding [ISO]
- GTP binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- deoxyribonuclease activity [ISO]
- enzyme binding [IPI]
- gamma-tubulin binding [IDA]
- identical protein binding [ISO]
- intermediate filament binding [IPI]
- magnesium ion binding [ISO]
- nucleoside diphosphate kinase activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- ribosomal small subunit binding [ISO]
- single-stranded DNA binding [IDA]
Gene Ontology Cellular Component
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID