BAIT
MAPK11
P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2
mitogen-activated protein kinase 11
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HOMER1
HOMER1F, Vesl-1
homer homolog 1 (Drosophila)
GO Process (14)
GO Function (9)
GO Component (14)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IDA]
- behavioral response to cocaine [ISO]
- chemical homeostasis within a tissue [ISO]
- circadian rhythm [IEP]
- positive regulation of calcium ion transport [ISO]
- protein localization to synapse [IDA]
- regulation of calcium ion import [ISO]
- regulation of cation channel activity [ISO]
- regulation of store-operated calcium entry [IBA, ISO]
- response to calcium ion [ISO]
- response to cocaine [IEP]
- response to nicotine [IEP]
- skeletal muscle contraction [ISO]
- skeletal muscle fiber development [ISO]
Gene Ontology Molecular Function- G-protein coupled glutamate receptor binding [IPI]
- identical protein binding [IPI]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IPI]
- protein heterodimerization activity [IPI]
- receptor binding [IDA]
- scaffold protein binding [IPI]
- type 5 metabotropic glutamate receptor binding [IPI]
- G-protein coupled glutamate receptor binding [IPI]
- identical protein binding [IPI]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IPI]
- protein heterodimerization activity [IPI]
- receptor binding [IDA]
- scaffold protein binding [IPI]
- type 5 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID