BAIT
MAPK11
P38b, Prkm11, Sapk2, Sapk2b, p38-2, p38beta, p38beta2
mitogen-activated protein kinase 11
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PTGIS
PGIS
prostaglandin I2 (prostacyclin) synthase
GO Process (15)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- apoptotic signaling pathway [ISO]
- cellular response to hypoxia [ISO, ISS]
- cellular response to interleukin-1 [ISO, ISS]
- cellular response to interleukin-6 [ISO, ISS]
- decidualization [ISO]
- embryo implantation [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO, ISS]
- negative regulation of inflammatory response [ISO, ISS]
- negative regulation of nitric oxide biosynthetic process [ISO, ISS]
- positive regulation of angiogenesis [ISO, ISS]
- positive regulation of execution phase of apoptosis [ISO, ISS]
- positive regulation of peroxisome proliferator activated receptor signaling pathway [ISO, ISS]
- prostaglandin biosynthetic process [IDA, ISO, ISS, TAS]
- regulation of apoptotic process [IBA]
- response to hypoxia [IMP]
Gene Ontology Molecular Function
Rattus norvegicus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
p38? MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway is essential for normal heart function. However, p38 also contributes to heart failure pathogenesis by affecting cardiomyocytes contractility and survival. To unravel part of the complex role of p38 in cardiac function, we performed an APEX2-based proximity assay in cultured neonatal rat ventricular myocytes and identified the protein interaction networks (interactomes) of ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2018; 1866(12);118557 [Pubmed: 31505169]
Throughput
- High Throughput
Additional Notes
- APEX2
Curated By
- BioGRID