BAIT
RAC2
EN-7, Gx, HSPC022, p21-Rac2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
GO Process (14)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- actin filament organization [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- lymphocyte aggregation [IMP]
- platelet activation [TAS]
- positive regulation of lamellipodium assembly [IMP]
- positive regulation of neutrophil chemotaxis [IMP]
- regulation of cell-substrate adhesion [IMP]
- regulation of hydrogen peroxide metabolic process [TAS]
- regulation of neutrophil migration [IMP]
- regulation of respiratory burst [IDA]
- regulation of small GTPase mediated signal transduction [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARHGDIB
D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2
Rho GDP dissociation inhibitor (GDI) beta
GO Process (9)
GO Function (0)
GO Component (5)
Gene Ontology Biological Process
- Rho protein signal transduction [TAS]
- actin cytoskeleton organization [TAS]
- cellular component movement [TAS]
- immune response [TAS]
- multicellular organismal development [TAS]
- negative regulation of cell adhesion [TAS]
- regulation of catalytic activity [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Cellular Component
Homo sapiens
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.
Rho family-specific guanine nucleotide dissociation inhibitors (RhoGDIs) decrease the rate of nucleotide dissociation and release Rho proteins such as RhoA, Rac and Cdc42 from membranes, forming tight complexes that shuttle between cytosol and membrane compartments. We have solved the crystal structure of a complex between the RhoGDI homolog LyGDI and GDP-bound Rac2, which are abundant in leukocytes, representing the cytosolic, ... [more]
Nat. Struct. Biol. Feb. 01, 2000; 7(2);122-6 [Pubmed: 10655614]
Throughput
- Low Throughput
Curated By
- BioGRID