HIPK2
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IDA]
- PML body organization [TAS]
- SMAD protein signal transduction [IDA]
- cellular response to hypoxia [TAS]
- erythrocyte differentiation [ISS]
- eye development [ISS]
- intrinsic apoptotic signaling pathway [NAS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [TAS]
- modulation by virus of host morphology or physiology [NAS]
- negative regulation of BMP signaling pathway [IMP]
- peptidyl-serine phosphorylation [ISS]
- peptidyl-threonine phosphorylation [ISS]
- positive regulation of JNK cascade [IMP]
- positive regulation of angiogenesis [IDA]
- positive regulation of protein binding [ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP]
- protein phosphorylation [IDA]
- regulation of cell cycle [TAS]
Gene Ontology Molecular Function
UBE2I
Gene Ontology Biological Process
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein sumoylation [IBA, ISO]
- protein ubiquitination [IBA, ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- HLH domain binding [IPI]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IBA, ISO]
- bHLH transcription factor binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- HLH domain binding [IPI]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IBA, ISO]
- bHLH transcription factor binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1.
Posttranslational modifications such as ubiquitination and phosphorylation play an important role in the regulation of cellular protein function. Homeodomain-interacting protein kinase 2 (HIPK2) is a member of the recently identified family of nuclear protein kinases that act as corepressors for homeodomain transcription factors. Here, we show that HIPK2 is regulated by a ubiquitin-like protein, SUMO-1. We demonstrate that HIPK2 localizes ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBE2I HIPK2 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID