BAIT

RNF183

5830442J12Rik, RP24-189G18.1
ring finger protein 183
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY

GGA3

golgi-associated, gamma adaptin ear containing, ARF binding protein 3
UPS Project
GO Process (1)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its ?1 subunit.

Okamoto T, Wu Y, Matsuhisa K, Saito A, Sakaue F, Imaizumi K, Kaneko M

We previously reported that RNF183, a member of the RING finger (RNF) protein family, is specifically expressed in the renal collecting duct and that RNF183 mRNA is induced by the activity of nuclear factor of activated T cells 5 (NFAT5), which regulates the transcription of essential proteins for adaptation to hypertonic conditions. The renal medulla is the only tissue that ... [more]

Biochem Biophys Res Commun Dec. 22, 2019; 521(4);1030-1035 [Pubmed: 31732153]

Throughput

  • High Throughput

Curated By

  • BioGRID