BAIT
RNF183
5830442J12Rik, RP24-189G18.1
ring finger protein 183
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
MAPRE2
EB1, EB2, RP1
microtubule-associated protein, RP/EB family, member 2
GO Process (2)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its ?1 subunit.
We previously reported that RNF183, a member of the RING finger (RNF) protein family, is specifically expressed in the renal collecting duct and that RNF183 mRNA is induced by the activity of nuclear factor of activated T cells 5 (NFAT5), which regulates the transcription of essential proteins for adaptation to hypertonic conditions. The renal medulla is the only tissue that ... [more]
Biochem Biophys Res Commun Dec. 22, 2019; 521(4);1030-1035 [Pubmed: 31732153]
Throughput
- High Throughput
Curated By
- BioGRID