KCNQ1
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [IMP]
- cardiac muscle contraction [IMP]
- cellular response to cAMP [IDA, IMP]
- cellular response to drug [IDA]
- cellular response to epinephrine stimulus [TAS]
- membrane repolarization during action potential [IDA]
- membrane repolarization during cardiac muscle cell action potential [IMP, TAS]
- positive regulation of potassium ion transmembrane transport [IDA]
- potassium ion export [IDA]
- potassium ion transmembrane transport [IDA]
- regulation of atrial cardiac muscle cell membrane repolarization [IMP]
- regulation of heart contraction [IC]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of membrane repolarization [IDA, IMP]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sensory perception of sound [TAS]
- synaptic transmission [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- calmodulin binding [IDA]
- delayed rectifier potassium channel activity [IDA]
- ion channel binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- protein phosphatase 1 binding [IDA]
- scaffold protein binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
- calmodulin binding [IDA]
- delayed rectifier potassium channel activity [IDA]
- ion channel binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- protein phosphatase 1 binding [IDA]
- scaffold protein binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
Gene Ontology Cellular Component
KCNQ2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.
Mutations in KCNQ K(+) channel genes underlie several human pathologies. KCNQ alpha-subunits form either homotetramers or hetero-oligomers with a restricted subset of other KCNQ alpha-subunits or with KCNE beta-subunits. KCNQ1 assembles with KCNE beta-subunits but not with other KCNQ alpha-subunits. By contrast, KCNQ3 interacts with KCNQ2, KCNQ4 and KCNQ5. Using a chimaeric strategy, we show that a cytoplasmic carboxy-terminal subunit ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID