CFHR3
Gene Ontology Cellular Component
C3
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- complement activation [IMP, TAS]
- complement activation, alternative pathway [TAS]
- immune response [TAS]
- innate immune response [TAS]
- positive regulation of G-protein coupled receptor protein signaling pathway [IDA]
- positive regulation of apoptotic cell clearance [IMP]
- positive regulation of glucose transport [IDA]
- positive regulation of lipid storage [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of complement activation [TAS]
- regulation of immune response [TAS]
- regulation of triglyceride biosynthetic process [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin.
The human factor H-related proteins FHR-3 and FHR4 are members of a family of proteins related to the complement factor H. Here, we report that the two proteins bind to the C3d region of complement C3b. The apparent K(A) values for the interactions of FHR-3 and FHR-4 with C3b are 7.5 x 10(6) M(-1) and 2.9 x 10(6) M(-1), respectively. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID