CD1D
Gene Ontology Biological Process
- T cell selection [TAS]
- antigen processing and presentation, endogenous lipid antigen via MHC class Ib [IDA]
- antigen processing and presentation, exogenous lipid antigen via MHC class Ib [IBA]
- detection of bacterium [TAS]
- heterotypic cell-cell adhesion [TAS]
- positive regulation of T cell proliferation [IDA]
- positive regulation of innate immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
P4HTM
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Human CD1d associates with prolyl-4-hydroxylase during its biosynthesis.
Recent studies have shown that the CD1 family of proteins present various glycolipid antigens to subsets of T cells. CD1d is expressed on human intestinal epithelial cells (IEC) and exists in two biochemical forms: 37-kDa, beta2-microglobulin (beta2m) independent, nonglycosylated, and 47-kDa, beta2m dependent, glycosylated forms. The biosynthetic pathways and the mechanisms of generation of these two biochemically distinct forms of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID