MSS51
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MDM38
Gene Ontology Biological Process
- cellular potassium ion homeostasis [IMP]
- mitochondrial respiratory chain complex III biogenesis [IGI, IMP]
- mitochondrial respiratory chain complex IV biogenesis [IGI, IMP]
- positive regulation of mitochondrial translation [IGI]
- potassium ion transport [IGI, IMP]
- protein insertion into mitochondrial membrane [IMP]
- proton transport [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis.
Mitochondria contain their own gene expression systems, including membrane-bound ribosomes dedicated to synthesizing a few hydrophobic subunits of the oxidative phosphorylation (OXPHOS) complexes. We used a proximity-dependent biotinylation technique, BioID, coupled with mass spectrometry to delineate in baker's yeast a comprehensive network of factors involved in biogenesis of mitochondrial encoded proteins. This mitochondrial gene expression network (MiGENet) encompasses proteins involved ... [more]
Quantitative Score
- 2.88105626 [log2fold change (FC)]
Throughput
- High Throughput
Additional Notes
- BioID
- Proximal mitochondrial proteins were detected using BioID analyses and proteins with a log2fold change >= 1.5 and a p-value =< 0.05 were considered significant.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MSS51 MDM38 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.7188 | BioGRID | 587669 | |
| MDM38 MSS51 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.7188 | BioGRID | 585159 |
Curated By
- BioGRID