BAIT
USP38
HP43.8KD
ubiquitin specific peptidase 38
GO Process (3)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CKB
B-CK, BCK, CKBB, HEL-211, HEL-S-29
creatine kinase, brain
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Deubiquitinase USP38 Promotes NHEJ Repair through Regulation of HDAC1 Activity and Regulates Cancer Cell Response to Genotoxic Insults.
The DNA damage response (DDR) is essential for maintaining genome integrity. Mounting evidence reveals that protein modifications play vital roles in the DDR. Here, we show that USP38 is involved in the DDR by regulating the activity of HDAC1. In response to DNA damage, USP38 interacted with HDAC1 and specifically removed the K63-linked ubiquitin chain promoting the deacetylase activity of ... [more]
Cancer Res Dec. 15, 2019; 80(4);719-731 [Pubmed: 31874856]
Throughput
- High Throughput
Additional Notes
- proteins were considered a positive hit if identified with 5 or more peptides with an FDR<0.01 and not found in the negative control
Curated By
- BioGRID