DDX58
Gene Ontology Biological Process
- RIG-I signaling pathway [IMP]
- cytoplasmic pattern recognition receptor signaling pathway in response to virus [TAS]
- detection of virus [IDA]
- innate immune response [IMP, TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of interferon-alpha production [IDA, IMP]
- positive regulation of interferon-beta production [IDA, IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IC]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell migration [IDA]
- regulation of type III interferon production [TAS]
- response to virus [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SNX5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
SNX5 inhibits RLR-mediated antiviral signaling by targeting RIG-I-VISA signalosome.
Upon invading the cell, the viral RNA is recognized by the RIG-I receptor located in the cytoplasm, causing the RIG-I receptor to be activated. The activated RIG-I receptor transmits downstream antiviral signals by interacting with the adaptor protein VISA located on the mitochondria, leading to the production of type ? interferons and crude inflammatory cytokine genes. Although there have been ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DDX58 SNX5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID