BAIT

NEAT1

LINC00084, NCRNA00084, TncRNA, VINC
nuclear paraspeckle assembly transcript 1 (non-protein coding)
Parkinson's Disease Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

PTPLAD1

B-IND1, BIND1, HACD3, HSPC121
protein tyrosine phosphatase-like A domain containing 1
GO Process (4)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer's Disease.

Huang Z, Zhao J, Wang W, Zhou J, Zhang J

Alzheimer's disease (AD) is the most common neurodegenerative disorder and the main cause of dementia among the elderly worldwide. Unfortunately, the mechanism of AD remains unclear, and no effective therapies are available yet. An increasing amount of studies have demonstrated that long non-coding RNAs (LncRNAs) play a notable role in the pathogenesis of plenty of human diseases, and they have ... [more]

Front Cell Neurosci Mar. 07, 2020; 14();28 [Pubmed: 32140098]

Throughput

  • High Throughput

Additional Notes

  • biotin-labeled NEAT1 lncRNA was mixed with cell lysates and associated hit/prey proteins identified by mass spectrometry as well as, in the cases of PINK1 and NEDD4L proteins, by western blotting

Curated By

  • BioGRID