BAIT
RSAD2
2510004L01Rik, cig33, cig5, vig1
radical S-adenosyl methionine domain containing 2
GO Process (9)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- CD4-positive, alpha-beta T cell activation [ISS]
- CD4-positive, alpha-beta T cell differentiation [ISS]
- defense response to virus [IDA]
- negative regulation of protein secretion [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of T-helper 2 cell cytokine production [ISS]
- positive regulation of toll-like receptor 7 signaling pathway [ISS]
- positive regulation of toll-like receptor 9 signaling pathway [ISS]
- response to virus [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UBE3C
HECTH2, tcag7.998
ubiquitin protein ligase E3C
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.
Mutation and prevalence of pathogenic viruses prompt the development of broad-spectrum antiviral strategies. Viperin is a potent antiviral protein that inhibits a broad range of viruses. Unexpectedly, we found that Viperin protein production in epithelium is defective in response to both viruses and interferons (IFNs). We further revealed that viruses and IFNs stimulate expression of the acetyltransferase HAT1, which induces ... [more]
Mol Cell Dec. 20, 2019; 77(4);734-747.e7 [Pubmed: 31812350]
Throughput
- High Throughput
Curated By
- BioGRID