CD2
Gene Ontology Biological Process
- T cell activation [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- cell surface receptor signaling pathway [TAS]
- heterotypic cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- membrane raft polarization [TAS]
- natural killer cell activation [NAS]
- positive regulation of interferon-gamma secretion [IDA]
- positive regulation of interleukin-8 secretion [IMP]
- positive regulation of myeloid dendritic cell activation [NAS]
- positive regulation of tumor necrosis factor production [IDA]
- regulation of T cell differentiation [NAS]
- single organismal cell-cell adhesion [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FYN
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell activation [IBA]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [IDA]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium ion transport [NAS]
- cell differentiation [IBA]
- cell migration [IBA]
- cellular response to peptide hormone stimulus [IBA]
- central nervous system development [IBA]
- epidermal growth factor receptor signaling pathway [TAS]
- feeding behavior [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [IBA, TAS]
- intracellular signal transduction [TAS]
- learning [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- protein phosphorylation [NAS]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of defense response to virus by virus [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Association of p59(fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain.
Human CD2 is a 50-55-kDa cell surface receptor specifically expressed on the surface of T lymphocytes and NK cells. Stimulation of human peripheral blood T cells with mitogenic pairs of anti-CD2 monoclonal antibodies (mAbs) is sufficient to induce interleukin-2 production and T cell proliferation in the absence of an antigen-specific signal through the T cell receptor. CD2 has been shown ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID