BAIT
CRK
CRKII, p38
v-crk avian sarcoma virus CT10 oncogene homolog
GO Process (11)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- activation of MAPKK activity [TAS]
- blood coagulation [TAS]
- ephrin receptor signaling pathway [IDA]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- regulation of Rho GTPase activity [IDA]
- regulation of actin cytoskeleton organization [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
EPHB3
ETK2, HEK2, TYRO6
EPH receptor B3
GO Process (19)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- angiogenesis [ISS]
- axon guidance [ISS]
- axonal fasciculation [ISS]
- cell migration [IDA]
- corpus callosum development [ISS]
- dendritic spine development [ISS]
- dendritic spine morphogenesis [ISS]
- digestive tract morphogenesis [ISS]
- ephrin receptor signaling pathway [IDA]
- palate development [ISS]
- positive regulation of synapse assembly [ISS]
- protein autophosphorylation [IDA]
- regulation of Cdc42 GTPase activity [IDA]
- regulation of Rac GTPase activity [IDA]
- regulation of axonogenesis [ISS]
- regulation of cell-cell adhesion [IDA]
- substrate adhesion-dependent cell spreading [IDA]
- thymus development [ISS]
- urogenital system development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.
HEK2 belongs to the family of EPH-related receptor tyrosine kinases (RTK) which are involved in axonal pathfinding and the formation of the embryonic body plan. The knowledge about intracellular pathways of signal transduction mediated by EPH-related receptors is still limited. Many of the known key players of cellular signalling contain Src homology 2 (SH2) domains, which recognize phosphotyrosine motifs in ... [more]
Oncogene Jul. 16, 1998; 17(2);255-60 [Pubmed: 9674711]
Throughput
- Low Throughput
Curated By
- BioGRID