VPS4A
Gene Ontology Biological Process
- ATP catabolic process [NAS]
- abscission [IMP]
- cytokinesis [IDA]
- cytokinesis checkpoint [IMP]
- cytoplasmic microtubule organization [IBA]
- endosomal transport [IMP, TAS]
- membrane organization [TAS]
- negative regulation of cytokinesis [IMP]
- positive regulation of exosomal secretion [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]
- vacuole organization [IBA]
- vesicle-mediated transport [IDA]
- viral budding via host ESCRT complex [IGI]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VPS4B
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- cytoplasmic microtubule organization [IBA]
- endosomal transport [IDA, IMP, TAS]
- endosome to lysosome transport via multivesicular body sorting pathway [IMP]
- intracellular cholesterol transport [IMP]
- membrane organization [TAS]
- negative regulation of exosomal secretion [IMP]
- positive regulation of exosomal secretion [IMP]
- positive regulation of viral release from host cell [IMP]
- regulation of viral process [IMP]
- response to lipid [IDA]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]
- vacuole organization [IBA]
- viral budding via host ESCRT complex [IGI]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions.
Genetic interactions, including synthetic lethal effects, can now be systematically identified in cancer cell lines using high-throughput genetic perturbation screens. Despite this advance, few genetic interactions have been reproduced across multiple studies and many appear highly context-specific. Here, by developing a new computational approach, we identified 220 robust driver-gene associated genetic interactions that can be reproduced across independent experiments and ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- VPS4A_KO cells were sensitive to siRNA targeting VPS4B
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VPS4A VPS4B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 1191805 | |
| VPS4A VPS4B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2220505 | |
| VPS4A VPS4B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3116412 | |
| VPS4B VPS4A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3149202 | |
| VPS4B VPS4A | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 2884948 |
Curated By
- BioGRID