A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

LDLRAD3 is a receptor for Venezuelan equine encephalitis virus.

Ma H, Kim AS, Kafai NM, Earnest JT, Shah AP, Case JB, Basore K, Gilliland TC, Sun C, Nelson CA, Thackray LB, Klimstra WB, Fremont DH, Diamond MS

Venezuelan equine encephalitis virus (VEEV) is a neurotropic alphavirus transmitted by mosquitoes that causes encephalitis and death in humans1. VEEV is a biodefence concern because of its potential for aerosol spread and the current lack of sufficient countermeasures. The host factors that are required for VEEV entry and infection remain poorly characterized. Here, using a genome-wide CRISPR-Cas9-based screen, we identify ... [more]

Nature Dec. 01, 2020; 588(7837);308-314 [Pubmed: 33208938]

Throughput

Low Throughput

Ontology Terms

phenotype: decreased susceptibility to viral infection (MP:0002410)

Curated By

BioGRID

Interaction Summary

LDLRAD3

Gene Ontology Biological Process

Gene Ontology Molecular Function

beta-amyloid binding [IDA]

Gene Ontology Cellular Component

B4GALT7