BAIT
CAMK2A
PK2CDD, PKCCD
calcium/calmodulin-dependent protein kinase II alpha
GO Process (13)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO, ISS]
- calcium ion transport [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IDA]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO, ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISO, ISS]
- protein autophosphorylation [IDA, IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO, ISS]
- regulation of neuronal synaptic plasticity [ISO, ISS]
- regulation of neurotransmitter secretion [ISO, ISS]
- response to ischemia [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ARHGEF2
rho/rac guanine nucleotide exchange factor (GEF) 2
GO Process (14)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- actin filament organization [ISO, ISS]
- cell morphogenesis [ISO, ISS]
- cellular response to muramyl dipeptide [ISO, ISS]
- establishment of mitotic spindle orientation [ISO]
- negative regulation of microtubule depolymerization [ISO, ISS]
- negative regulation of neurogenesis [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of interleukin-6 production [ISO, ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of tumor necrosis factor production [ISO, ISS]
- regulation of Rho protein signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID