BAIT
CAMK2A
PK2CDD, PKCCD
calcium/calmodulin-dependent protein kinase II alpha
GO Process (13)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO, ISS]
- calcium ion transport [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IDA]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO, ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISO, ISS]
- protein autophosphorylation [IDA, IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO, ISS]
- regulation of neuronal synaptic plasticity [ISO, ISS]
- regulation of neurotransmitter secretion [ISO, ISS]
- response to ischemia [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GSK3B
glycogen synthase kinase 3 beta
GO Process (56)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- ER overload response [ISO]
- Wnt signaling pathway [ISO]
- axonogenesis [ISO]
- canonical Wnt signaling pathway [ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [ISO]
- cell migration [ISO]
- cellular response to interleukin-3 [ISO, ISS]
- cellular response to mechanical stimulus [IDA]
- circadian rhythm [ISO, ISS]
- epithelial to mesenchymal transition [ISO, ISS]
- establishment of cell polarity [IDA]
- establishment or maintenance of cell polarity [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [ISO, ISS]
- fat cell differentiation [ISO]
- glycogen metabolic process [ISO]
- hippocampus development [ISO]
- hypermethylation of CpG island [ISO]
- intracellular signal transduction [ISO]
- myoblast fusion [ISO]
- myotube differentiation [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of NFAT protein import into nucleus [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cardiac muscle hypertrophy [ISO]
- negative regulation of dendrite morphogenesis [IMP]
- negative regulation of neuron maturation [ISO]
- negative regulation of neuron projection development [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein complex assembly [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [ISO, ISS]
- phosphorylation [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of axon extension [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISO, ISS]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein binding [ISO, ISS]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein export from nucleus [ISO]
- positive regulation of stem cell differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein export from nucleus [ISO]
- protein localization to microtubule [ISO]
- protein phosphorylation [IDA, ISO]
- re-entry into mitotic cell cycle [ISO]
- regulation of gene expression by genetic imprinting [ISO]
- regulation of microtubule-based process [ISO, ISS]
- regulation of neuron projection development [ISO]
- regulation of neuronal synaptic plasticity [IMP]
- response to drug [IEP]
- response to lithium ion [IEP]
- superior temporal gyrus development [ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [ISO]
- integrin binding [IPI]
- ionotropic glutamate receptor binding [IPI]
- kinase activity [ISO, ISS]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI, ISO]
- protein serine/threonine kinase activity [IDA, ISO, TAS]
- tau protein binding [IDA]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- ATP binding [IDA]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [ISO]
- integrin binding [IPI]
- ionotropic glutamate receptor binding [IPI]
- kinase activity [ISO, ISS]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI, ISO]
- protein serine/threonine kinase activity [IDA, ISO, TAS]
- tau protein binding [IDA]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- beta-catenin destruction complex [IDA, ISO]
- cell body [ISO]
- centrosome [ISO]
- cytoplasm [IDA, ISO, ISS, TAS]
- cytosol [IDA, ISO, TAS]
- dendritic shaft [ISO]
- dendritic spine [IDA]
- growth cone [ISO]
- membrane [IDA]
- membrane raft [IDA]
- membrane-bounded organelle [ISO]
- neuronal cell body [ISO]
- neuronal postsynaptic density [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, ISS]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [IDA]
- ribonucleoprotein complex [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID