BAIT
MAPK1
Erk2
mitogen activated protein kinase 1
GO Process (37)
GO Function (12)
GO Component (19)
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IMP, ISO]
- MAPK import into nucleus [IDA]
- T cell receptor signaling pathway [ISO]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [ISO]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO]
- cellular response to organic substance [IDA]
- cytosine metabolic process [ISO]
- intracellular signal transduction [IDA, TAS]
- labyrinthine layer blood vessel development [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO]
- mammary gland epithelial cell proliferation [ISO]
- negative regulation of cell differentiation [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [ISO, ISS]
- positive regulation of cell migration [IEP]
- positive regulation of cell proliferation [IEP]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [IEP]
- positive regulation of translation [IMP]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of protein stability [ISS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO, ISS]
- response to estrogen [IDA]
- response to exogenous dsRNA [ISO]
- response to lipopolysaccharide [ISO]
- response to toxic substance [IDA]
- sensory perception of pain [IMP]
- signal transduction [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [IDA]
- caveola [TAS]
- cytoplasm [ISO, ISS]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [ISO, TAS]
- mitotic spindle [ISS]
- nucleoplasm [IDA, ISO, TAS]
- nucleus [IDA, ISO, TAS]
- perikaryon [IDA]
- protein complex [IDA]
- pseudopodium [ISO]
Rattus norvegicus
PREY
MECP2
methyl CpG binding protein 2
GO Process (62)
GO Function (16)
GO Component (9)
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- behavioral fear response [ISO]
- brain development [ISO]
- cardiolipin metabolic process [ISO]
- catecholamine secretion [ISO]
- cellular biogenic amine metabolic process [ISO]
- cerebellum development [ISO]
- chromatin silencing [ISO]
- dendrite development [ISO]
- glucocorticoid metabolic process [ISO]
- glutamine metabolic process [ISO]
- heart development [IEP]
- histone acetylation [ISO]
- histone methylation [ISO]
- inositol metabolic process [ISO]
- learning [ISO]
- long-term memory [ISO]
- long-term synaptic potentiation [ISO]
- memory [ISO]
- mitochondrial electron transport, ubiquinol to cytochrome c [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of astrocyte differentiation [IDA]
- negative regulation of histone acetylation [ISO]
- negative regulation of histone methylation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neurological system process involved in regulation of systemic arterial blood pressure [ISO]
- neuromuscular process [ISO]
- neuromuscular process controlling posture [ISO]
- neuron differentiation [ISO]
- neuron maturation [ISO]
- neuron projection development [ISO]
- pathogenesis [ISO]
- phosphatidylcholine metabolic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of synapse assembly [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- post-embryonic development [ISO]
- proprioception [ISO]
- protein localization [ISO]
- regulation of DNA methylation [IEP, IMP]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of gene expression [ISO]
- regulation of gene expression by genetic imprinting [ISO]
- regulation of gene expression, epigenetic [ISO]
- regulation of respiratory gaseous exchange by neurological system process [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of transcription, DNA-templated [ISO]
- respiratory gaseous exchange [ISO]
- response to estradiol [IEP]
- response to hypoxia [ISO]
- response to ionizing radiation [IEP]
- response to lead ion [IEP]
- response to organic cyclic compound [IEP]
- sensory perception of pain [ISO]
- social behavior [ISO]
- startle response [ISO]
- synapse assembly [ISO]
- synaptic transmission [ISO]
- ventricular system development [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [ISO]
- double-stranded methylated DNA binding [IDA, ISO]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- histone deacetylase binding [IPI]
- mRNA binding [ISO]
- methyl-CpG binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein N-terminus binding [ISO]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- siRNA binding [ISO]
- transcription factor binding [ISO]
- unmethylated CpG binding [IDA]
- DNA binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [ISO]
- double-stranded methylated DNA binding [IDA, ISO]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- histone deacetylase binding [IPI]
- mRNA binding [ISO]
- methyl-CpG binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein N-terminus binding [ISO]
- protein domain specific binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- siRNA binding [ISO]
- transcription factor binding [ISO]
- unmethylated CpG binding [IDA]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID