BAIT
AKT3
Pkbg
v-akt murine thymoma viral oncogene homolog 3
GO Process (5)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PAK3
beta-PAK
p21 protein (Cdc42/Rac)-activated kinase 3
GO Process (13)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin cytoskeleton organization [IBA]
- activation of MAPK activity [ISO]
- axonogenesis [IBA, ISO, ISS]
- dendrite development [ISO, ISS]
- intracellular signal transduction [TAS]
- mitotic cell cycle [IBA]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of dendritic spine morphogenesis [IMP]
- positive regulation of neuron apoptotic process [IMP]
- protein phosphorylation [IDA]
- regulation of actin filament polymerization [ISO, ISS]
- regulation of neuron projection development [IMP]
Gene Ontology Molecular Function
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID