BAIT
CAMK2A
PK2CDD, PKCCD
calcium/calmodulin-dependent protein kinase II alpha
GO Process (13)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO, ISS]
- calcium ion transport [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IDA]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO, ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISO, ISS]
- protein autophosphorylation [IDA, IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO, ISS]
- regulation of neuronal synaptic plasticity [ISO, ISS]
- regulation of neurotransmitter secretion [ISO, ISS]
- response to ischemia [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PDE2A
Pde2, Pde2a2
phosphodiesterase 2A, cGMP-stimulated
GO Process (22)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- cAMP catabolic process [IDA, ISO]
- cAMP-mediated signaling [IMP, ISO]
- cGMP catabolic process [IDA, ISO]
- cGMP-mediated signaling [ISO, ISS]
- cellular response to cGMP [ISO, ISS]
- cellular response to drug [ISO, ISS]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO, ISS]
- cellular response to macrophage colony-stimulating factor stimulus [ISO, ISS]
- cellular response to mechanical stimulus [ISO, ISS]
- cellular response to transforming growth factor beta stimulus [ISO]
- establishment of endothelial barrier [IDA]
- metabolic process [ISO]
- monocyte differentiation [ISO]
- negative regulation of cAMP biosynthetic process [IMP, ISO]
- negative regulation of protein import into nucleus, translocation [ISO, ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- negative regulation of vascular permeability [ISO, ISS]
- positive regulation of gene expression [ISO]
- positive regulation of inflammatory response [ISO, ISS]
- positive regulation of vascular permeability [ISO, ISS]
- protein targeting to mitochondrion [IMP]
- regulation of cGMP metabolic process [ISO]
Gene Ontology Molecular Function- GAF domain binding [ISO]
- TPR domain binding [ISO]
- cAMP binding [IDA, ISO]
- cGMP binding [IDA, ISO]
- cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [IDA, ISO]
- cyclic-nucleotide phosphodiesterase activity [ISO, ISS]
- drug binding [ISO, ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA, ISO]
- GAF domain binding [ISO]
- TPR domain binding [ISO]
- cAMP binding [IDA, ISO]
- cGMP binding [IDA, ISO]
- cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [IDA, ISO]
- cyclic-nucleotide phosphodiesterase activity [ISO, ISS]
- drug binding [ISO, ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA, ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO, ISS]
- axon [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO, ISS]
- dendrite [ISO]
- endoplasmic reticulum [ISO, ISS]
- intracellular [ISO]
- membrane raft [IDA]
- mitochondrial matrix [IDA]
- nucleus [ISO, ISS]
- perinuclear region of cytoplasm [ISO, ISS]
- plasma membrane [ISO, ISS]
- presynaptic membrane [ISO, ISS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID