BAIT
CAMK2A
PK2CDD, PKCCD
calcium/calmodulin-dependent protein kinase II alpha
GO Process (13)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO, ISS]
- calcium ion transport [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IDA]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO, ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISO, ISS]
- protein autophosphorylation [IDA, IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO, ISS]
- regulation of neuronal synaptic plasticity [ISO, ISS]
- regulation of neurotransmitter secretion [ISO, ISS]
- response to ischemia [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PDE4B
PDE4/IVb, Pde4B1, Pde4B2, Pde4B3, Pde4B4
phosphodiesterase 4B, cAMP specific
GO Process (14)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISO]
- cAMP catabolic process [IDA, ISO]
- cellular response to drug [ISO]
- cellular response to epinephrine stimulus [ISO]
- cellular response to lipopolysaccharide [ISO]
- leukocyte migration [ISO]
- negative regulation of relaxation of cardiac muscle [ISO]
- neutrophil chemotaxis [ISO]
- neutrophil homeostasis [ISO]
- positive regulation of interferon-gamma production [ISO]
- positive regulation of interleukin-2 production [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of high voltage-gated calcium channel activity [ISO]
- smooth muscle contraction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID