BAIT
AKT3
Pkbg
v-akt murine thymoma viral oncogene homolog 3
GO Process (5)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
PICALM
Calm
phosphatidylinositol binding clathrin assembly protein
GO Process (25)
GO Function (7)
GO Component (19)
Gene Ontology Biological Process
- axonogenesis [IMP, ISO]
- cargo loading into vesicle [ISO, ISS]
- cell proliferation [ISO, ISS]
- clathrin coat assembly [IDA, ISO]
- clathrin-mediated endocytosis [ISO, ISS]
- dendrite morphogenesis [IMP, ISO]
- endosomal transport [ISO]
- hemopoiesis [ISO]
- iron ion homeostasis [ISO, ISS]
- iron ion import into cell [ISO, ISS]
- negative regulation of gene expression [ISO, ISS]
- negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [ISS]
- negative regulation of receptor-mediated endocytosis [ISO]
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISS]
- positive regulation of beta-amyloid formation [ISO, ISS]
- positive regulation of neuron death [ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO]
- receptor internalization [ISO]
- receptor-mediated endocytosis [ISO, ISS]
- regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISO, ISS]
- regulation of endocytosis [IMP, ISO]
- regulation of protein localization [ISO]
- regulation of protein transport [IMP]
- synaptic vesicle maturation [ISS]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- AP-2 adaptor complex [ISO]
- clathrin coat of coated pit [ISO]
- clathrin-coated vesicle [IDA]
- coated pit [ISO, ISS]
- endosome [IDA]
- intracellular [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- neurofibrillary tangle [ISO, ISS]
- neuronal cell body [ISO, ISS]
- neuronal postsynaptic density [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA]
- synapse [IDA]
- synaptic vesicle [IDA]
- vesicle [ISS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID