BAIT
MAPK1
Erk2
mitogen activated protein kinase 1
GO Process (37)
GO Function (12)
GO Component (19)
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IMP, ISO]
- MAPK import into nucleus [IDA]
- T cell receptor signaling pathway [ISO]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [ISO]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO]
- cellular response to organic substance [IDA]
- cytosine metabolic process [ISO]
- intracellular signal transduction [IDA, TAS]
- labyrinthine layer blood vessel development [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO]
- mammary gland epithelial cell proliferation [ISO]
- negative regulation of cell differentiation [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [ISO, ISS]
- positive regulation of cell migration [IEP]
- positive regulation of cell proliferation [IEP]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [IEP]
- positive regulation of translation [IMP]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of protein stability [ISS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO, ISS]
- response to estrogen [IDA]
- response to exogenous dsRNA [ISO]
- response to lipopolysaccharide [ISO]
- response to toxic substance [IDA]
- sensory perception of pain [IMP]
- signal transduction [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [IDA]
- caveola [TAS]
- cytoplasm [ISO, ISS]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [ISO, TAS]
- mitotic spindle [ISS]
- nucleoplasm [IDA, ISO, TAS]
- nucleus [IDA, ISO, TAS]
- perikaryon [IDA]
- protein complex [IDA]
- pseudopodium [ISO]
Rattus norvegicus
PREY
PPP3CB
Calna2
protein phosphatase 3, catalytic subunit, beta isozyme
GO Process (20)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- T cell differentiation [ISO]
- T cell homeostasis [ISO]
- calcineurin-NFAT signaling cascade [ISO]
- calcium ion-dependent exocytosis [ISO, ISS]
- cellular response to drug [ISO, ISS]
- dephosphorylation [ISO]
- heart development [ISO]
- locomotion involved in locomotory behavior [ISO]
- muscle cell cellular homeostasis [IEP]
- negative regulation of T cell mediated cytotoxicity [ISO]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein dephosphorylation [IDA, ISO]
- protein phosphorylation [ISO, ISS]
- regulation of gene expression [ISO]
- regulation of insulin secretion [IDA]
- response to amphetamine [IEP]
- response to cytokine [ISO]
- social behavior [ISO]
Gene Ontology Molecular Function- calcium ion binding [ISO, ISS]
- calcium-dependent protein serine/threonine phosphatase activity [IDA]
- calmodulin binding [IDA, ISO]
- calmodulin-dependent protein phosphatase activity [ISO, ISS]
- drug binding [ISO, ISS]
- enzyme binding [ISO, ISS]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [IDA]
- protein phosphatase 2B binding [ISO, ISS]
- protein serine/threonine phosphatase activity [ISO, TAS]
- calcium ion binding [ISO, ISS]
- calcium-dependent protein serine/threonine phosphatase activity [IDA]
- calmodulin binding [IDA, ISO]
- calmodulin-dependent protein phosphatase activity [ISO, ISS]
- drug binding [ISO, ISS]
- enzyme binding [ISO, ISS]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [IDA]
- protein phosphatase 2B binding [ISO, ISS]
- protein serine/threonine phosphatase activity [ISO, TAS]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID