BAIT
MAPK1
Erk2
mitogen activated protein kinase 1
GO Process (37)
GO Function (12)
GO Component (19)
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IMP, ISO]
- MAPK import into nucleus [IDA]
- T cell receptor signaling pathway [ISO]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [ISO]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO]
- cellular response to organic substance [IDA]
- cytosine metabolic process [ISO]
- intracellular signal transduction [IDA, TAS]
- labyrinthine layer blood vessel development [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO]
- mammary gland epithelial cell proliferation [ISO]
- negative regulation of cell differentiation [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [ISO, ISS]
- positive regulation of cell migration [IEP]
- positive regulation of cell proliferation [IEP]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [IEP]
- positive regulation of translation [IMP]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of protein stability [ISS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO, ISS]
- response to estrogen [IDA]
- response to exogenous dsRNA [ISO]
- response to lipopolysaccharide [ISO]
- response to toxic substance [IDA]
- sensory perception of pain [IMP]
- signal transduction [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [IDA]
- caveola [TAS]
- cytoplasm [ISO, ISS]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [ISO, TAS]
- mitotic spindle [ISS]
- nucleoplasm [IDA, ISO, TAS]
- nucleus [IDA, ISO, TAS]
- perikaryon [IDA]
- protein complex [IDA]
- pseudopodium [ISO]
Rattus norvegicus
PREY
PRKCB
Pkcb, Prkcb1
protein kinase C, beta
GO Process (25)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- B cell activation [ISO, ISS]
- B cell receptor signaling pathway [ISO, ISS]
- calcium ion transport [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to carbohydrate stimulus [ISO]
- dibenzo-p-dioxin metabolic process [IEP]
- histone H3-T6 phosphorylation [ISO, ISS]
- intracellular signal transduction [NAS]
- negative regulation of glucose transport [ISO, ISS]
- negative regulation of insulin receptor signaling pathway [IDA]
- positive regulation of B cell receptor signaling pathway [ISO, ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of angiogenesis [ISO, ISS]
- positive regulation of odontogenesis of dentin-containing tooth [IEP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO, ISS]
- protein phosphorylation [ISO]
- regulation of dopamine secretion [IMP]
- regulation of growth [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- response to drug [IMP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to hypoxia [ISO]
- response to vitamin D [IEP]
Gene Ontology Molecular Function- androgen receptor binding [ISO, ISS]
- calcium channel regulator activity [ISO]
- chromatin binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-T6 specific) [ISO, ISS]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO, ISS]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [ISO]
- androgen receptor binding [ISO, ISS]
- calcium channel regulator activity [ISO]
- chromatin binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-T6 specific) [ISO, ISS]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO, ISS]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID