BAIT
CAMK2A
PK2CDD, PKCCD
calcium/calmodulin-dependent protein kinase II alpha
GO Process (13)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO, ISS]
- calcium ion transport [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IDA]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO, ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISO, ISS]
- protein autophosphorylation [IDA, IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO, ISS]
- regulation of neuronal synaptic plasticity [ISO, ISS]
- regulation of neurotransmitter secretion [ISO, ISS]
- response to ischemia [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAB8A
Mel, Rab8
RAB8A, member RAS oncogene family
GO Process (17)
GO Function (5)
GO Component (23)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Golgi vesicle fusion to target membrane [IBA, ISO]
- Rab protein signal transduction [IBA]
- axonogenesis [IMP]
- cellular response to insulin stimulus [IMP]
- cilium assembly [ISO, ISS]
- glucose homeostasis [IC]
- intracellular protein transport [IBA]
- positive regulation of glucose import [IC]
- protein localization to plasma membrane [IDA]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- regulation of long-term neuronal synaptic plasticity [IDA, IMP]
- regulation of protein localization [IMP]
- regulation of protein transport [IDA, IMP]
- synaptic vesicle exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- centrosome [ISO]
- ciliary basal body [ISO]
- cilium [ISO, ISS]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic vesicle membrane [TAS]
- dendrite [IDA]
- endosome [IBA]
- extracellular vesicular exosome [ISO]
- neuronal cell body [IDA]
- nonmotile primary cilium [ISO]
- nucleolus [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- phagocytic vesicle [ISO, ISS]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- primary cilium [ISO]
- recycling endosome [ISO]
- recycling endosome membrane [ISO, ISS]
- secretory granule membrane [IBA]
- synaptic vesicle [IBA]
- trans-Golgi network transport vesicle [IBA, ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID