BAIT
CAMK2A
PK2CDD, PKCCD
calcium/calmodulin-dependent protein kinase II alpha
GO Process (13)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO, ISS]
- calcium ion transport [ISO, ISS]
- ionotropic glutamate receptor signaling pathway [IDA]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of calcium ion transport [ISO, ISS]
- positive regulation of cardiac muscle cell apoptotic process [ISO, ISS]
- protein autophosphorylation [IDA, IMP, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of mitochondrial membrane permeability involved in apoptotic process [ISO, ISS]
- regulation of neuronal synaptic plasticity [ISO, ISS]
- regulation of neurotransmitter secretion [ISO, ISS]
- response to ischemia [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAPGEF2
PDZ-GEF1, RA-GEF-1, nRap GEP
Rap guanine nucleotide exchange factor (GEF) 2
GO Process (32)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO, ISS]
- Rap protein signal transduction [ISO, ISS]
- adenylate cyclase-activating adrenergic receptor signaling pathway [ISO, ISS]
- blood vessel development [ISO, ISS]
- brain-derived neurotrophic factor receptor signaling pathway [IMP]
- cAMP-mediated signaling [ISO, ISS]
- cellular response to cAMP [ISO, ISS]
- cellular response to cGMP [ISO, ISS]
- cellular response to nerve growth factor stimulus [IDA]
- establishment of endothelial barrier [ISO, ISS]
- forebrain neuron development [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of dendrite morphogenesis [ISO, ISS]
- negative regulation of melanin biosynthetic process [ISO, ISS]
- nerve growth factor signaling pathway [IDA]
- neuron migration [ISO, ISS]
- neuron projection development [ISO, ISS]
- neuropeptide signaling pathway [ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO, ISS]
- positive regulation of Rap GTPase activity [IDA, IMP, ISO]
- positive regulation of Ras GTPase activity [ISO, ISS]
- positive regulation of cAMP-dependent protein kinase activity [ISO, ISS]
- positive regulation of cAMP-mediated signaling [ISO, ISS]
- positive regulation of dendritic cell apoptotic process [ISO, ISS]
- positive regulation of neuron migration [ISO, ISS]
- positive regulation of neuron projection development [IMP]
- positive regulation of protein binding [ISO, ISS]
- positive regulation of protein kinase activity [IMP, ISO, ISS]
- positive regulation of vasculogenesis [ISO, ISS]
- regulation of cell junction assembly [ISO, ISS]
- regulation of synaptic plasticity [IDA]
- ventricular system development [ISO, ISS]
Gene Ontology Molecular Function- PDZ domain binding [ISO, ISS]
- Rap GTPase activator activity [ISO]
- Rap guanyl-nucleotide exchange factor activity [IMP, ISO, ISS]
- Ras guanyl-nucleotide exchange factor activity [ISO, ISS]
- WW domain binding [ISO, ISS]
- beta-1 adrenergic receptor binding [ISO, ISS]
- cAMP binding [ISO, ISS]
- cGMP binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- PDZ domain binding [ISO, ISS]
- Rap GTPase activator activity [ISO]
- Rap guanyl-nucleotide exchange factor activity [IMP, ISO, ISS]
- Ras guanyl-nucleotide exchange factor activity [ISO, ISS]
- WW domain binding [ISO, ISS]
- beta-1 adrenergic receptor binding [ISO, ISS]
- cAMP binding [ISO, ISS]
- cGMP binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Structural Analysis of Hippocampal Kinase Signal Transduction.
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly ... [more]
ACS Chem Neurosci Dec. 19, 2017; 9(12);3072-3085 [Pubmed: 30053369]
Throughput
- Low Throughput
Curated By
- BioGRID