BAIT
NUPR1
COM1, P8
nuclear protein, transcriptional regulator, 1
GO Process (1)
GO Function (0)
GO Component (2)
Homo sapiens
PREY
SCRIB
CRIB1, SCRB1, SCRIB1, Vartul
scribbled planar cell polarity protein
GO Process (13)
GO Function (1)
GO Component (9)
Gene Ontology Biological Process
- activation of Rac GTPase activity [IMP]
- apoptotic process involved in morphogenesis [IMP]
- cell migration [IMP]
- cell proliferation [IDA]
- establishment of apical/basal cell polarity [IMP]
- mammary gland duct morphogenesis [ISS]
- negative regulation of mitotic cell cycle [IDA]
- neural tube closure [IMP]
- positive chemotaxis [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of receptor recycling [IMP]
- protein localization to adherens junction [IMP]
- single organismal cell-cell adhesion [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.
Establishing the interactome of the cancer-associated stress protein Nuclear Protein 1 (NUPR1), we found that it binds to several hundreds of proteins, including proteins involved in nuclear translocation, DNA repair, and key factors of the SUMO pathway. We demonstrated that the NUPR1 inhibitor ZZW-115, an organic synthetic molecule, competes with importins for the binding to the NLS region of NUPR1, ... [more]
JCI Insight Sep. 17, 2020; 5(18); [Pubmed: 32780723]
Throughput
- High Throughput
Curated By
- BioGRID