BAIT
HDAC5
AI426555, Hdac4, mHDA1, mKIAA0600, RP23-461C4.2
histone deacetylase 5
GO Process (29)
GO Function (13)
GO Component (8)
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- cellular response to fluid shear stress [IDA]
- chromatin modification [TAS]
- heart development [IGI]
- histone deacetylation [ISO, TAS]
- inflammatory response [TAS]
- multicellular organismal response to stress [IMP]
- negative regulation of cell migration involved in sprouting angiogenesis [ISO]
- negative regulation of myotube differentiation [ISO]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of striated muscle tissue development [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, TAS]
- nervous system development [TAS]
- osteoblast development [IMP]
- positive regulation of neural precursor cell proliferation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stem cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- regulation of gene expression, epigenetic [ISO]
- regulation of myotube differentiation [IDA]
- regulation of protein binding [ISO]
- regulation of skeletal muscle fiber development [IGI]
- regulation of striated muscle cell differentiation [IGI]
- renal tubule morphogenesis [IMP]
- response to cocaine [IDA, IMP]
- response to drug [ISO]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II transcription factor binding [IPI]
- chromatin binding [ISO]
- core promoter binding [ISO]
- core promoter sequence-specific DNA binding [IDA]
- histone deacetylase activity [ISO, TAS]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase binding [IPI]
- repressing transcription factor binding [ISO]
- transcription corepressor activity [IDA, IGI]
- transcription factor binding [IPI, ISO, TAS]
- transcription regulatory region DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II transcription factor binding [IPI]
- chromatin binding [ISO]
- core promoter binding [ISO]
- core promoter sequence-specific DNA binding [IDA]
- histone deacetylase activity [ISO, TAS]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase binding [IPI]
- repressing transcription factor binding [ISO]
- transcription corepressor activity [IDA, IGI]
- transcription factor binding [IPI, ISO, TAS]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
PLG
AI649309, Pg
plasminogen
GO Process (13)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- blood coagulation [ISO]
- extracellular matrix disassembly [ISO]
- labyrinthine layer blood vessel development [IMP]
- mononuclear cell migration [IMP]
- muscle cell cellular homeostasis [IMP]
- myoblast differentiation [IMP]
- negative regulation of angiogenesis [TAS]
- negative regulation of cell-substrate adhesion [ISO]
- negative regulation of fibrinolysis [ISO]
- positive regulation of fibrinolysis [ISO]
- proteolysis involved in cellular protein catabolic process [ISO]
- tissue regeneration [IMP]
- trophoblast giant cell differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.
Huntington's disease (HD) is a monogenic disorder, driven by the expansion of a trinucleotide (CAG) repeat within the huntingtin (Htt) gene and culminating in neuronal degeneration in the brain, predominantly in the striatum and cortex. Histone deacetylase 4 (Hdac4) was previously found to contribute to the disease progression, providing a potential therapeutic target. Hdac4 knockdown reduced accumulation of misfolded Htt ... [more]
Mol Cell Proteomics Dec. 09, 2018; 18(8 suppl 1);S92-S113 [Pubmed: 31040226]
Throughput
- High Throughput
Curated By
- BioGRID