BAIT

HDAC4

4932408F19Rik, AI047285
histone deacetylase 4
GO Process (33)
GO Function (15)
GO Component (12)

Gene Ontology Biological Process

Mus musculus
PREY

GPR158

5330427M13Rik, mKIAA1136, RP23-133B16.1
G protein-coupled receptor 158
GO Process (2)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

Federspiel JD, Greco TM, Lum KK, Cristea IM

Huntington's disease (HD) is a monogenic disorder, driven by the expansion of a trinucleotide (CAG) repeat within the huntingtin (Htt) gene and culminating in neuronal degeneration in the brain, predominantly in the striatum and cortex. Histone deacetylase 4 (Hdac4) was previously found to contribute to the disease progression, providing a potential therapeutic target. Hdac4 knockdown reduced accumulation of misfolded Htt ... [more]

Mol Cell Proteomics Dec. 09, 2018; 18(8 suppl 1);S92-S113 [Pubmed: 31040226]

Throughput

  • High Throughput

Curated By

  • BioGRID