BAIT
HDAC4
4932408F19Rik, AI047285
histone deacetylase 4
GO Process (33)
GO Function (15)
GO Component (12)
Gene Ontology Biological Process
- chromatin remodeling [ISO]
- histone H3 deacetylation [ISO]
- histone H4 deacetylation [ISO]
- histone deacetylation [ISO]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of glycolytic process [IMP]
- negative regulation of myotube differentiation [ISO]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- osteoblast development [IMP]
- peptidyl-lysine deacetylation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein sumoylation [ISO]
- positive regulation of reactive oxygen species biosynthetic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [IMP]
- protein deacetylation [IDA]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of gene expression, epigenetic [ISO]
- regulation of protein binding [ISO]
- regulation of skeletal muscle fiber development [IGI]
- regulation of striated muscle cell differentiation [IGI]
- response to denervation involved in regulation of muscle adaptation [IMP]
- response to drug [ISO]
- response to interleukin-1 [ISO]
- skeletal system development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- activating transcription factor binding [ISO]
- core promoter binding [ISO]
- histone deacetylase activity [ISO]
- histone deacetylase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- protein kinase binding [IPI]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [ISO]
- transcription corepressor activity [IGI]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- zinc ion binding [ISO]
- DNA binding [IDA]
- activating transcription factor binding [ISO]
- core promoter binding [ISO]
- histone deacetylase activity [ISO]
- histone deacetylase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- protein kinase binding [IPI]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [ISO]
- transcription corepressor activity [IGI]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
TRIO
6720464I07Rik, AA408740, Solo
triple functional domain (PTPRF interacting)
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.
Huntington's disease (HD) is a monogenic disorder, driven by the expansion of a trinucleotide (CAG) repeat within the huntingtin (Htt) gene and culminating in neuronal degeneration in the brain, predominantly in the striatum and cortex. Histone deacetylase 4 (Hdac4) was previously found to contribute to the disease progression, providing a potential therapeutic target. Hdac4 knockdown reduced accumulation of misfolded Htt ... [more]
Mol Cell Proteomics Dec. 09, 2018; 18(8 suppl 1);S92-S113 [Pubmed: 31040226]
Throughput
- High Throughput
Curated By
- BioGRID