BAIT
HDAC4
4932408F19Rik, AI047285
histone deacetylase 4
GO Process (33)
GO Function (15)
GO Component (12)
Gene Ontology Biological Process
- chromatin remodeling [ISO]
- histone H3 deacetylation [ISO]
- histone H4 deacetylation [ISO]
- histone deacetylation [ISO]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of glycolytic process [IMP]
- negative regulation of myotube differentiation [ISO]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- osteoblast development [IMP]
- peptidyl-lysine deacetylation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein sumoylation [ISO]
- positive regulation of reactive oxygen species biosynthetic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [IMP]
- protein deacetylation [IDA]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of gene expression, epigenetic [ISO]
- regulation of protein binding [ISO]
- regulation of skeletal muscle fiber development [IGI]
- regulation of striated muscle cell differentiation [IGI]
- response to denervation involved in regulation of muscle adaptation [IMP]
- response to drug [ISO]
- response to interleukin-1 [ISO]
- skeletal system development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- activating transcription factor binding [ISO]
- core promoter binding [ISO]
- histone deacetylase activity [ISO]
- histone deacetylase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- protein kinase binding [IPI]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [ISO]
- transcription corepressor activity [IGI]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- zinc ion binding [ISO]
- DNA binding [IDA]
- activating transcription factor binding [ISO]
- core promoter binding [ISO]
- histone deacetylase activity [ISO]
- histone deacetylase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- protein kinase binding [IPI]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [ISO]
- transcription corepressor activity [IGI]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
CACNA1A
APCA, BI, Caca1a, Cacnl1a4, Cav2.1, Ccha1a, EA2, FHM, HPCA, MHP, MHP1, SCA6, alpha1A, la, nmf352, rkr, tg
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
GO Process (50)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- adult walking behavior [IGI, IMP]
- behavioral response to pain [IMP]
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IGI]
- calcium ion transport [IMP, ISO]
- calcium ion-dependent exocytosis [IMP]
- calcium ion-dependent exocytosis of neurotransmitter [IMP]
- cell death [ISO]
- cell growth [IMP]
- cellular chloride ion homeostasis [IMP]
- central nervous system neuron differentiation [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellar Purkinje cell layer development [IMP]
- cerebellar molecular layer development [IMP]
- cerebellum maturation [IMP]
- dendrite morphogenesis [IMP]
- gamma-aminobutyric acid secretion [IMP]
- gamma-aminobutyric acid signaling pathway [IMP]
- glucose metabolic process [IMP]
- hormone metabolic process [IMP]
- membrane depolarization [IMP]
- membrane depolarization during action potential [IBA]
- musculoskeletal movement, spinal reflex action [IMP]
- negative regulation of hormone biosynthetic process [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neurological system process [IMP]
- neuromuscular process [IGI, IMP]
- neuromuscular process controlling balance [IMP]
- neuromuscular synaptic transmission [IMP]
- neuron-neuron synaptic transmission [IMP]
- neurotransmitter metabolic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- receptor clustering [IMP]
- regulation of acetylcholine secretion, neurotransmission [IMP]
- regulation of axonogenesis [IMP]
- regulation of calcium ion-dependent exocytosis [IDA]
- regulation of ion transmembrane transport [IGI]
- regulation of membrane potential [IMP]
- response to pain [IMP]
- rhythmic synaptic transmission [IMP]
- sensory perception of pain [ISO]
- spinal cord motor neuron differentiation [IMP]
- sulfur amino acid metabolic process [IMP]
- synapse assembly [IMP]
- synaptic transmission [IMP, ISO]
- synaptic transmission, GABAergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- thyroid hormone metabolic process [IMP]
- transmission of nerve impulse [IMP]
- vestibular nucleus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.
Huntington's disease (HD) is a monogenic disorder, driven by the expansion of a trinucleotide (CAG) repeat within the huntingtin (Htt) gene and culminating in neuronal degeneration in the brain, predominantly in the striatum and cortex. Histone deacetylase 4 (Hdac4) was previously found to contribute to the disease progression, providing a potential therapeutic target. Hdac4 knockdown reduced accumulation of misfolded Htt ... [more]
Mol Cell Proteomics Dec. 09, 2018; 18(8 suppl 1);S92-S113 [Pubmed: 31040226]
Throughput
- High Throughput
Curated By
- BioGRID