POL2
Gene Ontology Biological Process
- DNA replication proofreading [IMP]
- DNA-dependent DNA replication [IDA]
- base-excision repair [IMP]
- double-strand break repair [IMP]
- double-strand break repair via nonhomologous end joining [IGI, IMP]
- error-prone translesion synthesis [IDA]
- gene conversion [IMP]
- heterochromatin organization involved in chromatin silencing [IGI, IMP]
- intra-S DNA damage checkpoint [IGI, IMP, IPI]
- leading strand elongation [IMP]
- mitotic DNA replication checkpoint [IMP]
- mitotic sister chromatid cohesion [IMP]
- nucleotide-excision repair, DNA gap filling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SEN1
Gene Ontology Biological Process
- DNA-dependent DNA replication maintenance of fidelity [IMP]
- DNA-templated transcription, termination [IMP]
- mRNA 3'-end processing [IMP]
- mRNA polyadenylation [IMP]
- rRNA processing [IMP]
- regulation of transcription from RNA polymerase II promoter in response to DNA damage [IMP]
- snRNA processing [IMP]
- snoRNA 3'-end processing [IMP]
- tRNA processing [IMP]
- termination of RNA polymerase II transcription [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
DNA polymerase ? relies on a unique domain for efficient replisome assembly and strand synthesis.
DNA polymerase epsilon (Pol ?) is required for genome duplication and tumor suppression. It supports both replisome assembly and leading strand synthesis; however, the underlying mechanisms remain to be elucidated. Here we report that a conserved domain within the Pol ? catalytic core influences both of these replication steps in budding yeast. Modeling cancer-associated mutations in this domain reveals its ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SEN1 POL2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| POL2 SEN1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.3062 | BioGRID | 1950147 |
Curated By
- BioGRID