IFIH1
Gene Ontology Biological Process
- cytoplasmic pattern recognition receptor signaling pathway in response to virus [TAS]
- detection of virus [TAS]
- innate immune response [TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of interferon-alpha production [IMP, TAS]
- positive regulation of interferon-beta production [IMP, TAS]
- protein sumoylation [IDA]
- regulation of type III interferon production [TAS]
- response to virus [TAS]
Gene Ontology Molecular Function
DHX58
Gene Ontology Biological Process
- negative regulation of MDA-5 signaling pathway [IMP]
- negative regulation of RIG-I signaling pathway [IDA, IMP]
- negative regulation of innate immune response [IDA]
- negative regulation of type I interferon production [IDA]
- positive regulation of MDA-5 signaling pathway [ISS]
- positive regulation of RIG-I signaling pathway [ISS]
- positive regulation of type I interferon production [ISS]
- regulation of innate immune response [IDA]
- response to virus [ISS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), establishes an antiviral state by upregulating interferon (IFN)-stimulated genes (ISGs). Among these is ISG15, the mechanistic roles of which in innate immunity still remain enigmatic. In the present study, we report that ISG15 conjugation is essential for antiviral IFN responses mediated by the viral ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID