BAIT
SLC6A4
5-HTT, AI323329, Htt, Sert, RP23-100P23.1
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
GO Process (22)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- brain morphogenesis [IMP]
- cellular response to cGMP [ISO]
- cellular response to organic substance [IDA]
- circadian rhythm [ISO]
- memory [ISO]
- monoamine transport [ISO]
- negative regulation of cerebellar granule cell precursor proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of organ growth [IMP]
- negative regulation of synaptic transmission, dopaminergic [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of gene expression [IMP]
- protein homooligomerization [ISO]
- protein oligomerization [ISO]
- response to toxic substance [ISO]
- serotonin transport [IMP, ISO]
- serotonin uptake [IDA, IMP, ISO]
- social behavior [IGI]
- sodium ion transmembrane transport [ISO]
- sperm ejaculation [ISO]
- thalamus development [ISO]
- vasoconstriction [ISO]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
DLG1
B130052P05Rik, Dlgh1, E-dlg/SAP97, SAP-97, SAP97, mKIAA4187
discs, large homolog 1 (Drosophila)
GO Process (40)
GO Function (13)
GO Component (32)
Gene Ontology Biological Process
- T cell activation [IMP]
- T cell cytokine production [IMP]
- actin filament organization [ISO]
- activation of protein kinase activity [IMP]
- amyloid precursor protein metabolic process [IGI]
- branching involved in ureteric bud morphogenesis [IMP]
- cortical actin cytoskeleton organization [ISO]
- embryonic skeletal system morphogenesis [IMP]
- endothelial cell proliferation [ISO]
- establishment or maintenance of epithelial cell apical/basal polarity [IBA]
- hard palate development [IMP]
- immunological synapse formation [IMP]
- lens development in camera-type eye [IMP]
- membrane raft organization [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein kinase B signaling [IMP]
- nucleotide phosphorylation [IBA]
- peristalsis [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of developmental growth [TAS]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of multicellular organism growth [TAS]
- positive regulation of potassium ion transport [ISO]
- protein localization [IGI, IMP]
- protein localization to plasma membrane [ISO]
- receptor clustering [IBA]
- receptor localization to synapse [IBA]
- regulation of membrane potential [IGI, ISO]
- regulation of myelination [IMP]
- regulation of protein localization [ISO]
- reproductive structure development [IMP]
- single organismal cell-cell adhesion [ISO]
- smooth muscle tissue development [IMP]
- synaptic transmission [IBA]
- tight junction assembly [ISO]
- tissue morphogenesis [IMP]
- ureteric bud development [IMP]
Gene Ontology Molecular Function- L27 domain binding [ISO]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IMP]
- protein kinase binding [ISO]
- L27 domain binding [ISO]
- PDZ domain binding [ISO]
- guanylate kinase activity [IBA]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IBA, ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IMP]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MPP7-DLG1-LIN7 complex [ISO]
- T-tubule [ISO]
- basal lamina [IDA]
- basal plasma membrane [ISO]
- basolateral plasma membrane [IDA, ISO, TAS]
- cell junction [IDA, ISO]
- cell projection membrane [IDA]
- cell-cell adherens junction [TAS]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA]
- ionotropic glutamate receptor complex [IBA]
- lateral loop [IDA]
- lateral plasma membrane [IDA]
- membrane raft [IDA]
- microtubule [ISO]
- myelin sheath abaxonal region [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- node of Ranvier [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA]
- presynaptic membrane [ISO]
- synapse [IDA]
- tight junction [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.
Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release from serotonergic neurons in the brain and enteric nervous systems, among other sites. Accumulating evidence suggests that SERT is dynamically regulated in distinct activity states ... [more]
Front Mol Neurosci Jun. 26, 2020; 13();89 [Pubmed: 32581705]
Throughput
- High Throughput
Curated By
- BioGRID