BAIT
SLC6A4
5-HTT, AI323329, Htt, Sert, RP23-100P23.1
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
GO Process (22)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- brain morphogenesis [IMP]
- cellular response to cGMP [ISO]
- cellular response to organic substance [IDA]
- circadian rhythm [ISO]
- memory [ISO]
- monoamine transport [ISO]
- negative regulation of cerebellar granule cell precursor proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of organ growth [IMP]
- negative regulation of synaptic transmission, dopaminergic [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of gene expression [IMP]
- protein homooligomerization [ISO]
- protein oligomerization [ISO]
- response to toxic substance [ISO]
- serotonin transport [IMP, ISO]
- serotonin uptake [IDA, IMP, ISO]
- social behavior [IGI]
- sodium ion transmembrane transport [ISO]
- sperm ejaculation [ISO]
- thalamus development [ISO]
- vasoconstriction [ISO]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
GRIA1
2900051M01Rik, Glr-1, Glr1, GluA1, GluR-A, GluRA, Glur-1, Glur1, HIPA1, gluR-K1, RP23-102H8.1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
GO Process (14)
GO Function (15)
GO Component (26)
Gene Ontology Biological Process
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- long term synaptic depression [IGI]
- long-term memory [IMP, ISO]
- neuronal action potential [ISO]
- positive regulation of membrane potential [ISO]
- positive regulation of synaptic transmission [ISO]
- receptor internalization [IMP, ISO]
- regulation of receptor recycling [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- response to toxic substance [ISO]
- synaptic transmission [IGI]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- G-protein beta-subunit binding [ISO]
- PDZ domain binding [ISO]
- adenylate cyclase binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- beta-2 adrenergic receptor binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- myosin V binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase A binding [ISO]
- protein kinase binding [ISO]
- small GTPase binding [ISO]
- G-protein alpha-subunit binding [ISO]
- G-protein beta-subunit binding [ISO]
- PDZ domain binding [ISO]
- adenylate cyclase binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- beta-2 adrenergic receptor binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- myosin V binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase A binding [ISO]
- protein kinase binding [ISO]
- small GTPase binding [ISO]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [ISO]
- axonal spine [IDA]
- cell surface [IDA, ISO]
- cytosol [ISO]
- dendrite [IDA]
- dendrite membrane [IDA]
- dendritic shaft [ISO]
- dendritic spine [IDA, ISO]
- dendritic spine membrane [ISO]
- early endosome [ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [ISO]
- ionotropic glutamate receptor complex [IDA]
- membrane [IDA]
- neuromuscular junction [ISO]
- neuron projection [IDA, ISO]
- neuron spine [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- protein complex [ISO]
- recycling endosome [ISO]
- synapse [IDA, ISO]
- synaptic vesicle [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.
Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release from serotonergic neurons in the brain and enteric nervous systems, among other sites. Accumulating evidence suggests that SERT is dynamically regulated in distinct activity states ... [more]
Front Mol Neurosci Jun. 26, 2020; 13();89 [Pubmed: 32581705]
Throughput
- High Throughput
Curated By
- BioGRID