BAIT
SLC6A4
5-HTT, AI323329, Htt, Sert, RP23-100P23.1
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
GO Process (22)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- brain morphogenesis [IMP]
- cellular response to cGMP [ISO]
- cellular response to organic substance [IDA]
- circadian rhythm [ISO]
- memory [ISO]
- monoamine transport [ISO]
- negative regulation of cerebellar granule cell precursor proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of organ growth [IMP]
- negative regulation of synaptic transmission, dopaminergic [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of gene expression [IMP]
- protein homooligomerization [ISO]
- protein oligomerization [ISO]
- response to toxic substance [ISO]
- serotonin transport [IMP, ISO]
- serotonin uptake [IDA, IMP, ISO]
- social behavior [IGI]
- sodium ion transmembrane transport [ISO]
- sperm ejaculation [ISO]
- thalamus development [ISO]
- vasoconstriction [ISO]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
DNAJA3
1200003J13Rik, 1810053A11Rik, C81173, Tid-1, Tid1l
DnaJ (Hsp40) homolog, subfamily A, member 3
GO Process (29)
GO Function (10)
GO Component (13)
Gene Ontology Biological Process
- T cell differentiation in thymus [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- activation-induced cell death of T cells [IMP]
- apoptotic process [IMP]
- cell aging [IDA]
- embryo development [IMP]
- mitochondrial DNA replication [IMP]
- mitochondrion organization [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISA, ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of interferon-gamma-mediated signaling pathway [ISO]
- negative regulation of programmed cell death [IMP]
- negative regulation of protein kinase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- neuromuscular junction development [IMP, ISO]
- positive regulation of T cell proliferation [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein folding [ISO]
- protein refolding [IBA]
- protein stabilization [ISO]
- regulation of apoptotic process [IBA]
- regulation of catalytic activity [IDA]
- response to interferon-gamma [ISO]
- skeletal muscle acetylcholine-gated channel clustering [IMP]
- small GTPase mediated signal transduction [IDA]
Gene Ontology Molecular Function- Hsp70 protein binding [ISO]
- NF-kappaB binding [ISO]
- chaperone binding [IBA]
- interferon-gamma receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor tyrosine kinase binding [IPI]
- small GTPase regulator activity [IDA]
- transcription factor binding [ISO]
- unfolded protein binding [IPI]
- Hsp70 protein binding [ISO]
- NF-kappaB binding [ISO]
- chaperone binding [IBA]
- interferon-gamma receptor binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor tyrosine kinase binding [IPI]
- small GTPase regulator activity [IDA]
- transcription factor binding [ISO]
- unfolded protein binding [IPI]
Gene Ontology Cellular Component
- I-kappaB/NF-kappaB complex [ISO]
- IkappaB kinase complex [ISO]
- actin filament [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- extrinsic component of plasma membrane [IDA]
- intracellular membrane-bounded organelle [ISO]
- mitochondrial matrix [ISO]
- mitochondrial nucleoid [ISO]
- mitochondrion [IDA, IMP, ISO]
- neuromuscular junction [IDA]
- nucleus [IDA, ISO]
- postsynaptic membrane [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.
Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release from serotonergic neurons in the brain and enteric nervous systems, among other sites. Accumulating evidence suggests that SERT is dynamically regulated in distinct activity states ... [more]
Front Mol Neurosci Jun. 26, 2020; 13();89 [Pubmed: 32581705]
Throughput
- High Throughput
Curated By
- BioGRID