BAIT
SLC6A4
5-HTT, AI323329, Htt, Sert, RP23-100P23.1
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
GO Process (22)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- brain morphogenesis [IMP]
- cellular response to cGMP [ISO]
- cellular response to organic substance [IDA]
- circadian rhythm [ISO]
- memory [ISO]
- monoamine transport [ISO]
- negative regulation of cerebellar granule cell precursor proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of organ growth [IMP]
- negative regulation of synaptic transmission, dopaminergic [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of gene expression [IMP]
- protein homooligomerization [ISO]
- protein oligomerization [ISO]
- response to toxic substance [ISO]
- serotonin transport [IMP, ISO]
- serotonin uptake [IDA, IMP, ISO]
- social behavior [IGI]
- sodium ion transmembrane transport [ISO]
- sperm ejaculation [ISO]
- thalamus development [ISO]
- vasoconstriction [ISO]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
RAPGEF2
5830453M24Rik, CNRasGEF, Pdzgef1, RA-GEF-1, mKIAA0313, nRapGEP
Rap guanine nucleotide exchange factor (GEF) 2
GO Process (32)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- Rap protein signal transduction [ISO]
- adenylate cyclase-activating adrenergic receptor signaling pathway [ISO]
- blood vessel development [IMP]
- brain-derived neurotrophic factor receptor signaling pathway [ISO]
- cAMP-mediated signaling [IDA, ISO]
- cellular response to cAMP [IDA, IMP, ISO]
- cellular response to cGMP [ISO]
- cellular response to nerve growth factor stimulus [ISO]
- establishment of endothelial barrier [ISO]
- forebrain neuron development [IMP]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of dendrite morphogenesis [IMP, ISO]
- negative regulation of melanin biosynthetic process [IMP]
- nerve growth factor signaling pathway [ISO]
- neuron migration [IMP]
- neuron projection development [IMP, ISO]
- neuropeptide signaling pathway [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP, ISO]
- positive regulation of Rap GTPase activity [IDA, IMP, ISO]
- positive regulation of Ras GTPase activity [IMP, ISO]
- positive regulation of cAMP-dependent protein kinase activity [IMP, ISO]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of dendritic cell apoptotic process [IMP, ISO]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of protein binding [IDA]
- positive regulation of protein kinase activity [IDA, ISO]
- positive regulation of vasculogenesis [IMP]
- regulation of cell junction assembly [ISO]
- regulation of synaptic plasticity [ISO]
- ventricular system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.
Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release from serotonergic neurons in the brain and enteric nervous systems, among other sites. Accumulating evidence suggests that SERT is dynamically regulated in distinct activity states ... [more]
Front Mol Neurosci Jun. 26, 2020; 13();89 [Pubmed: 32581705]
Throughput
- High Throughput
Curated By
- BioGRID